Giant's Bethesda Row was 24-hours in the past, and Giant continues to have a 24-hour store in the Georgetown Square shopping center north of town on Old Georgetown Road. CVS operates two 24-hour stores in downtown Bethesda, one diagonally across from the Bradley Boulevard Safeway, and one at Wisconsin and Cheltenham across from 7-Eleven and Fairmont Plaza. Both CVS stores carry a limited-but-decent selection of groceries.
Obviously, a 24-hour Harris Teeter at 8300 Wisconsin will be more convenient for those in the Woodmont Triangle or East Bethesda, particularly if they prefer to walk to the store for a handful of items. But for those closer or driving (with the latter being the vast majority of shoppers), the future is now.